The turbine manufacturer signed the letter with Lake Erie Alternative Power (LEAP), a developer planning to build ten wind clusters offshore of Ohio, Pennsylvania and New York.
A Siemens spokesman said the turbine used would likely be a 3.6MW model. However, the letter is not itself a sales agreement.
Siemens is to examine the possibility of starting local production and assembly facilities. The company said it is also looking to use suppliers in the Great Lakes area.
LEAP says it will build over two million sq ft of warehouse and factory space, plus 500,000 square feet of office space, to accommodate Siemens and the supply chain.
The project consists of six phases totalling 5,040MW of wind power, plus 280MW of hydrokinetic and 130MW of solar power.
LEAP plans to build ten clusters of 50 to 200 turbines each, totalling 1,400 turbines, with each cluster connected to an offshore substation.
It hopes to have the wind project operational in 2018.
Other wind proposals for the Great Lakes include a 20MW pilot project offshore of Cleveland, Ohio by the non-profit Lake Erie Energy Development Corporation (LEEDCo) and developer Great Lakes Ohio Wind.
The New York Power Authority (NYPA) issued a request for proposals to gauge interest in development on Lake Erie or Lake Ontario, and received submissions from five developers.
But, the authority says the project fundamentals are not strong enough to support the cost of such a project.