The site in Nellor, Andhra Pradesh, currently hires roughly 500 people, which will increase to 1,000 people after a second phase to the site is completed later this year.
Gamesa's new site will produce blades for its G114-2MW turbine that has been adapted for wind conditions in India.
"Inauguration of this factory fortifies Gamesa's industrial presence in India, a country in which we have cemented our position as the leading OEM," said Gamesa India CEO Ramesh Kymal.
Gamesa announced the site last May, after receiving the first orders in India for the G114 turbine in February 2016.
The new factory is Gamesa's third manufacturing facility in the subcontinent. It already has a blade factory in Gujarat and a nacelle factory in Tamil Nadu.
The nacelle factory, opened in 2013, was expanded in 2014 to accommodate manufacturing processes for the G114 turbine. There is also a repair centre in Chennai, in east India.
India is Gamesa's biggest market, contributing 34% of the completed sales total in the first nine months of 2016, up from 28% in 2015.