According to reports, the man had been working on the hilltop wind farm and was on his way down when the incident occurred.
A statement by Lancashire Police said: "Police were called to an incident at Scout Moor Quarry involving an 8-axe mobile crane. The crane appears to have left the road before coming to a stop and trapping the driver. The driver sadly received fatal injuries."
A joint investigation by police and the Health and Safety Executive is underway. Peel Energy, which owns the wind farm, was unavailable for comment.
A crane operator was recently killed in an accident at Agua Doce wind farm in Brazil in the south of the country, though exact details are unknown.